International Space Station National Laboratory

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Laboratory

Science in Space for the Benefit of Humanity

The ISS National
Laboratory Missions &
Launches 2025 Annual
Report Orbital Edge
Accelerator Upward International Space
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Missions & Launches

Science and R&D Going to Station

The ISS National
Laboratory Missions &
Launches 2025 Annual
Report Orbital Edge
Accelerator Upward International Space
Station Quiz

2025 Annual Report

View the Annual Report

The ISS National
Laboratory Missions &
Launches 2025 Annual
Report Orbital Edge
Accelerator Upward International Space
Station Quiz

Orbital Edge Accelerator

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The ISS National
Laboratory Missions &
Launches 2025 Annual
Report Orbital Edge
Accelerator Upward International Space
Station Quiz

Upward

How Space is Opening
a Window into the Brain

The ISS National
Laboratory Missions &
Launches 2025 Annual
Report Orbital Edge
Accelerator Upward International Space
Station Quiz

International Space
Station Quiz

Test your knowledge about the ISS

The ISS National
Laboratory Missions &
Launches 2025 Annual
Report Orbital Edge
Accelerator Upward International Space
Station Quiz

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News & Updates

CASIS celebrates 15 years of managing the ISS National Laboratory and more than 1,000 payloads delivered.

September 2, 2026

ISS National Lab Reaches 1,000-Payload Milestone as CASIS Celebrates 15 Years of Leadership

"When I think about our milestone of 1,000 payloads, what stands out is the incredible range of people and ideas behind it,"...

Brain organoids grown in Alysson Muotri’s lab cluster in a culture dish.

August 18, 2026

Brain Organoid Studies on the ISS Move Closer to New Treatments

A feature in Upward, the official magazine of the ISS National Laboratory®, follows two research teams using brain organoids in...

August 12, 2026

Eight Emerging Startups Selected for ISS National Lab’s Orbital Edge Accelerator Program

The program is being conducted in partnership with returning global investment partners Cook Inlet Region, Inc., E2MC, and...

The REACCH system at NASA's Ames Research Center for preflight testing.

July 16, 2026

Orbital “Tow Truck” Could Tackle Space Debris Problem

Through ISS National Laboratory-sponsored testing, Kall Morris Inc. successfully demonstrated its REACCH system, a robotic...

LambdaVision CEO Nicole Wagner working with bacteriorhodopsin, the purple protein used to create the company's artificial retinas.

June 10, 2026

Biotech Startup Turns to Space to Manufacture Artificial Retinas for Treating Blindness

Artificial retinas produced in microgravityThe condition of perceived weightlessness created when an object is in free fall, for example when an object is in orbital motion. Microgravity alters many observable phenomena within the physical and life sciences, allowing scientists to study things in ways not possible on Earth. The International Space Station provides access to a persistent microgravity environment. show markedly improved uniformity, optical performance, and reproducibility compared...

Tiffany Hennessa (left), U.S. Naval Research Laboratory (NRL) research biologist, and Zheng Wang, NRL research biologist, analyze a microbial sample in Washington, D.C. Scientists at NRL sent microbial samples to the ISS to investigate how microgravity affects microbial metabolism and biomaterial production.

June 4, 2026

Microbes Reveal Missing Link in Space Manufacturing

Researchers at the U.S. Naval Research Laboratory (NRL) studied engineered Escherichia coli designed to produce melanin, a...

ISS National Lab panel, "Space Research for a Healthy Future," at ASCEND 2026 in Washington, D.C., May 19.

May 29, 2026

Looking to the Future from a Space-based Lab

Collectively, the sessions underscored the pivotal role the orbiting laboratory has played in advancing science, enabling...

The POLARIS experiment undergoes ground-based testing ahead of integration with the MISSE Flight Facility outside the ISS.

May 13, 2026

Antarctic Microbes Put Survival to the Test in Space

The ISS National Laboratory®-sponsored investigation will leverage the MISSE Flight FacilityThe Materials International Space Station Experiment Flight Facility is a hardware platform on the exterior of the ISS that provides exposure to the harsh space conditions for the accelerated testing of materials and technologies with important applications both in space and on Earth. This ISS National Lab commercial facility is owned and operated by Aegis Aerospace., a permanent platform mounted...

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International Space Station National Laboratory

13 hours ago

As CASIS(Abbreviation: CASIS™) The nonprofit organization that manages the ISS National Lab, which receives at least 50 percent of the U.S. research allocation on the International Space Station to facilitate research that benefits humanity (NASA manages the other 50% and focuses on research for space exploration purposes). marks 15 years as manager of the ISS National Laboratory®, we're celebrating a major milestone: more than 1,000 ISS National Lab-sponsored payloads launched to the orbiting laboratory. From biotechnology and pharmaceuticals to advanced materials, Earth observation, and in-space manufacturing, these investigations showcase the breadth of innovation enabled through the ISS National Lab.

Read the full press release: ow.ly/HvEG50ZIfGH

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The International Space Station (ISS) National Laboratory

Solving some of the world’s most pressing challenges through space-based research.

Where? In space.
Low Earth orbit(Abbreviation: LEO) The orbit around the Earth that extends up to an altitude of 2,000 km (1,200 miles) from Earth’s surface. The International Space Station’s orbit is in LEO, at an altitude of approximately 250 miles. (LEO), approximately 250 miles above the Earth.

Learn More About the ISS National Lab

Research in Space Benefits Humanity

Improving the quality of
life for patients with cancer
and other diseases.

Manufacturing tissues
in space for
regenerative medicine.

Advancing technology
to withstand
harsh conditions.

Growing crops in
remote environments
with limited resources.

EXPLORE RESULTS FROM RESEARCH CONDUCTED IN SPACE

Upward Volume 9, Issue 2 Available Now

In this issue’s cover story, discover how brain organoids on the ISS are helping researchers study aging, neurodegeneration, and disease-relevant changes linked to Alzheimer’s, Parkinson’s, and Rett syndrome. Other features discuss how unexpected findings from Sanofi’s space research could help improve vaccines and how a new holographic microscope could one day help scientists find life on distant worlds.

Download the Upward Issue

Photo documentation of the Materials ISS Experiment Flight Facility (MISSE-FF) platform aboard the International Space Station.

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National Lab research announcements (NLRAs) seek proposals that advance R&D in key areas with demonstrated potential to develop into sustainable markets and benefit humanity.

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Explore the current issue of Upward

News & Updates

ISS National Lab Reaches 1,000-Payload Milestone as CASIS Celebrates 15 Years of Leadership

Brain Organoid Studies on the ISS Move Closer to New Treatments

Eight Emerging Startups Selected for ISS National Lab’s Orbital Edge Accelerator Program

Orbital “Tow Truck” Could Tackle Space Debris Problem

Biotech Startup Turns to Space to Manufacture Artificial Retinas for Treating Blindness

Microbes Reveal Missing Link in Space Manufacturing

Looking to the Future from a Space-based Lab

Antarctic Microbes Put Survival to the Test in Space

The International Space Station (ISS) National Laboratory

Research in Space Benefits Humanity

Improving the quality of
life for patients with cancer
and other diseases.

Manufacturing tissues
in space for
regenerative medicine.

Advancing technology
to withstand
harsh conditions.

Growing crops in
remote environments
with limited resources.

EXPLORE RESULTS FROM RESEARCH CONDUCTED IN SPACE

Upward Volume 9, Issue 2 Available Now

looking for a research opportunity?

ready to EXPLOre?

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for the Benefit of Humanity

Explore the current issue of Upward

News & Updates

ISS National Lab Reaches 1,000-Payload Milestone as CASIS Celebrates 15 Years of Leadership

Brain Organoid Studies on the ISS Move Closer to New Treatments

Eight Emerging Startups Selected for ISS National Lab’s Orbital Edge Accelerator Program

Orbital “Tow Truck” Could Tackle Space Debris Problem

Biotech Startup Turns to Space to Manufacture Artificial Retinas for Treating Blindness

Microbes Reveal Missing Link in Space Manufacturing

Looking to the Future from a Space-based Lab

Antarctic Microbes Put Survival to the Test in Space

The International Space Station (ISS) National Laboratory

Research in Space Benefits Humanity

Improving the quality of life for patients with cancer and other diseases. arrow

Manufacturing tissues in space for regenerative medicine. arrow

Advancing technology to withstand harsh conditions. arrow

Growing crops in remote environments with limited resources. arrow

EXPLORE RESULTS FROM RESEARCH CONDUCTED IN SPACE

Upward Volume 9, Issue 2 Available Now

looking for a research opportunity?

ready to EXPLOre?

Join our mailing list to receive the latest ISS National Lab news and updates.

Improving the quality of
life for patients with cancer
and other diseases.

Manufacturing tissues
in space for
regenerative medicine.

Advancing technology
to withstand
harsh conditions.

Growing crops in
remote environments
with limited resources.