NASA astronaut Christina Koch works on the University of Washington kidney tissue chip investigation inside the Life Sciences Glovebox onboard the ISS.

Open Period: 7/25/2024 – 10/18/2024

Tissue Chips in Space 2.0: Translational Multi-Organ Tissue Chip Systems for Drug Efficacy,...

The purpose of this ISS National Lab Research Announcement is to solicit proposals for applied R&D to demonstrate space-based manufacturing and production activities in microgravity.

Past Opportunity  
NASA astronaut Peggy Whitson works on the Oncolinx investigation onboard the ISS.

Open Period: 7/10/2024 – 10/28/2024

Technology in Space Prize 2024 (Funded by Boeing and CASIS in Partnership with MassChallenge)

The prize is open to startups that participate in a MassChallenge program and provides an opportunity to utilize the ISS National Lab to conduct innovative research and technology development (R&D).

Past Opportunity  
The MISSE Flight Facility, a commercially available orbital research facility that resides externally onboard the ISS, offers researchers the ability to test concepts in the extreme environment of space.

Open Period: 5/14/2024 – 10/16/2024

NLRA 2024-7: Technology Advancement and Applied Research Leveraging the ISS National Lab

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstration.

Past Opportunity  
NASA astronaut and Expedition 65 Flight Engineer Megan McArthur works in the Microgravity Science Glovebox on the ISS.

Open Period: 3/6/2024 – 7/15/2024

NLRA 2024-6: In-space Production Applications: Advanced Materials and Manufacturing

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstrations.

Past Opportunity  
Space Station Ambassador and educator, Laura Tomlin participating in a reduced gravity flight as part of the Embedded Teachers Program

Open Period: 2/27/2024 – 7/1/2024

NLRA 2024-5 Leveraging the International Space Station for STEM Education and Workforce...

The purpose of this NLRA is to solicit proposals for applied research and development seeking to demonstrate space-based biomanufacturing activities in microgravity.

Past Opportunity  
ESA astronaut Alexander Gerst and NASA astronaut Reid Wiseman work in the Microgravity Science Glovebox onboard the ISS

Open Period: 1/9/2024 – 5/7/2024

NLRA 2024-4 Technology Advancement and Applied Research Leveraging the ISS National Lab

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstration.

Past Opportunity  
European Space Agency astronaut Alexander Gerst, Expedition 40 flight engineer.

Open Period: 10/31/2023-3/4/2024

NSF/CASIS 2024 Collaboration on Transport Phenomena Research on the ISS to Benefit Life on...

The purpose of this solicitation is to attract proposals that make use of the ISS National Lab for flight research projects in the field of transport phenomena.

Past Opportunity  
iss062e120658 (April 2, 2020) NASA astronaut and Expedition 62 Flight Engineer Jessica Meir conducts cardiac research in the Life Sciences Glovebox located in the Japanese Kibo laboratory module. The Engineered Heart Tissues investigation could promote a better understanding of cardiac function in microgravity which would be useful for drug development and other applications related to heart conditions on Earth.

Open Period: 10/26/2023-3/15/2024

NSF/CASIS 2024 Collaboration on Tissue Engineering and Mechanobiology on the ISS to Benefit...

The purpose of this solicitation is to attract proposals that make use of the ISS National Lab for flight research projects in the field of biomedical engineering.

Past Opportunity  
iss065e154567 (June 30, 2021) Expedition 65 Commander Akihiko Hoshide of the Japan Aerospace Exploration Agency works inside the Microgravity Science Glovebox for the InSPACE 4 advanced materials study today that seeks to improve the strength and safety of Earth and space systems.

Open Period: Cycle 1 - 9/15/2022 – 3/29/2023
Cycle 2 - 2/28/2023 – 7/17/2023
Cycle 3 - 5/15/2023 – 10/9/2023

NLRA 2023-7: Technology Advancement and Applied Research Leveraging the ISS National Lab

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstrations.

Past Opportunity  
The Small Satellite Orbital Deployer (SSOD), in the grasp of the Kibo laboratory robotic arm, is photographed by an Expedition 38 crew member on the International Space Station as it deploys a set of NanoRacks CubeSats. The CubeSats program contains a variety of experiments such as Earth observations and advanced electronics testing.

Open Period: Cycle 1 - 9/15/2022 – 3/29/2023
Cycle 2 - 2/28/2023 – 7/17/2023
Cycle 3 - 5/15/2023 – 10/9/2023

NLRA 2023-8: Technology Advancement and Applied Research Leveraging the ISS National Lab

The purpose of this NLRA is to solicit proposals focused on flight investigations within applied R&D, translational medicine, technology readiness level maturation, and technology demonstration.

Past Opportunity  
iss065e085491 (June 3, 2021) NASA astronaut and Expedition 65 Flight Engineer Megan McArthur loads protein crystallography plates with protein solutions for the Real time Protein Crystal Growth experiment. The biotechnology study demonstrates new methods for producing high quality protein crystals in microgravity. Results may help identify new targets and develop better drugs to treat a variety of diseases on Earth and advance the commercialization of low Earth orbit.

Open Period: 10/4/2023 – 3/11/2024

NLRA 2024-1: In-Space Production Applications: Tissue Engineering and Biomanufacturing

The purpose of this NLRA is to solicit proposals for applied research and development seeking to demonstrate space-based biomanufacturing activities in microgravity.

Past Opportunity  
Igniting Innovation research opportunity

Open Period: 8/8/2023 – 3/15/2024

NLRA 2023-10 Igniting Innovation: Science in Space to Cure Disease on Earth

This NLRA is issued in collaboration with NASA BPS and seeks proposals for flight research on the ISS to address the goals of the Cancer MoonshotSM initiative.

Past Opportunity