America’s First Automated Bioprinter for Spaceflight Launching to ISS National Lab on SpaceX CRS-18

SS047e050792 (04/10/2016) --- The SpaceX Dragon cargo craft approaches to be grappled by the International Space Station Expedition 47 crew. This view is from the Cupola where the primary controls of the Canadarm 2 are located. Crewmembers use the robotic arm to grapple the spaceship before berthing it to the Earth-facing port on the Harmony module. The spacecraft delivered about 7,000 pounds of science and research investigations, including the Bigelow Expandable Activity Module, known as BEAM.
Media Credit: NASA
KENNEDY SPACE CENTER (FL), July 17, 2019 – A new facility will be launching to the International Space Station (ISSInternational Space Station) aboard SpaceX’s 18th commercial resupply services (CRS-18) mission, seeking to enable cutting-edge biotechnology research onboard the orbiting research laboratory. Techshot, a commercial facility partner, has partnered with NASANational Aeronautics and Space Administration and the ISS U.S. National Laboratory to launch the first American bioprinter, known as the 3D BioFabrication Facility (BFF(Abbreviation: BFF) The BFF is a 3D bioprinter on the ISS capable of printing human tissue from bioinks mixed with living cells. This ISS National Lab commercial facility is owned and operated by Redwire Space.). The BFF is slated to launch to the space station no earlier than July 24, 6:24 p.m. EDT aboard SpaceX’s Dragon spacecraft.
While researchers on Earth have had limited success in printing human elements like bones and cartilage, the ability for them to manufacture soft human tissue, such as blood vessels, has proven to be much more difficult. Specifically, the bioinks used in 3D bioprinting have a low viscosity, and on Earth, scientists must use scaffolding to support bioprinted structures and prevent them from collapsing. However, this scaffolding makes it difficult to construct void spaces needed in tissues. Bioprinting in microgravityThe condition of perceived weightlessness created when an object is in free fall, for example when an object is in orbital motion. Microgravity alters many observable phenomena within the physical and life sciences, allowing scientists to study things in ways not possible on Earth. The International Space Station provides access to a persistent microgravity environment. could prove beneficial because scaffolding is not needed to keep printed structures from collapsing, allowing scientists to overcome what has been a significant hurdle in ground-based biomanufacturing of human organs.
To further assist in the printing of human elements on the space station through the BFF, Techshot has partnered with nScrypt, widely regarded as one of the most reputable 3D-printing companies in the world. As mentioned, one of the constraints to bioprinting on Earth are the bioinks used in keeping formation of printed elements. nScrypt’s patented SmartPump Micro-Dispensing tool head enables precise placement of bioink, thereby enabling stronger formation of printed materials. Together, these two companies will seek to validate the BFF by attempting initially simple engineering prints, followed by more complex cardiac-like tissue, and placing the prints in Techshot’s cell-culturing system to strengthen the tissue over time. Once the tissue is viable and self-supporting, it will be sent back to Earth for further analysis.
According to the CDC, on any given day in the United States, an estimated 75,000 people are on the active waiting list for organs, far exceeding the organs available for patients. While the road to assembling a human lung or other organs is likely still many years away, the space station is enabling researchers and engineers the ability to develop, test, and validate new facilities that could have dramatic impacts on patient care back on Earth. Moreover, through the emergence of new facilities on the space station that are available for ISS National Lab users (more than 15 commercial facilities have been installed since 2012), the orbiting laboratory is evolving to the needs of the modern day research community, providing more opportunities for groundbreaking, innovative science.
To learn more about the BFF, please visit; https://techshot.com/bioprinter/.
To learn more about ISS National Lab-sponsored payloads on SpaceX CRS-18, visit our launch coverage page.
Media Contact:
Patrick O’Neill
(321) 480-1054
PONeill@issnationallab.org
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About the International Space Station (ISS) U.S. National Laboratory: In 2005, Congress designated the U.S. portion of the ISS as the nation’s newest national laboratory to optimize its use for improving quality of life on Earth, promoting collaboration among diverse users, and advancing science, technology, engineering, and mathematics (STEM) education. This unique laboratory environment is available for use by non-NASA U.S. government agencies, academic institutions, and the private sector. The ISS National Lab manages access to the permanent microgravity research environment, a powerful vantage point in low Earth orbit(Abbreviation: LEO) The orbit around the Earth that extends up to an altitude of 2,000 km (1,200 miles) from Earth’s surface. The International Space Station’s orbit is in LEO, at an altitude of approximately 250 miles., and the extreme and varied conditions of space.
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