MicroQuin to Launch Cancer Research on Northrop Grumman CRS-17

KENNEDY SPACE CENTER (FL), February 17, 2022 – An investigation from biotechnology startup MicroQuin launching to the International Space Station (ISSInternational Space Station) on Northrop Grumman’s 17th Commercial Resupply Services (CRS) aims to better understand the onset and progression of cancer. The project will use 3D cell culture to examine cell signaling pathways involved in tumorigenesis (the process by which normal cells transform into cancer cells). MicroQuin will also observe how cancer cells respond to a new cancer therapeutic the company has developed.

MicroQuin was awarded a grant for this project through the Technology in Space PrizeA prize that provides grant funding for business startups participating in the MassChallenge startup accelerator program to conduct innovative research and technology development utilizing the ISS National Lab. The prize is funded by the Center for the Advancement of Science in Space, which manages the ISS National Lab, and Boeing., funded by Boeing and the Center for the Advancement of Science in Space, Inc., manager of the ISS National Laboratory, in partnership with the MassChallenge startup accelerator program.

The investigation, supported by ISS National Lab Commercial Service ProviderImplementation Partners that own and operate commercial facilities for the support of research on the ISS or are developing future facilities. BioServe Space Technologies, will use microgravityThe condition of perceived weightlessness created when an object is in free fall, for example when an object is in orbital motion. Microgravity alters many observable phenomena within the physical and life sciences, allowing scientists to study things in ways not possible on Earth. The International Space Station provides access to a persistent microgravity environment. conditions on the ISS to grow 3D cultures of prostate and breast cancer cells as well as healthy cells. The research team will characterize cell structure, gene expression, and cell signaling in the 3D cultures of the cancer cells in comparison with healthy cells.

Cells behave differently in microgravity, forming 3D structures that more closely resemble the growth and behavior of cells inside the human body. According to Scott Robinson, president and chief science officer of MicroQuin, this type of cell growth is difficult to achieve on Earth, even with the help of scaffolding. The stress of microgravity also induces changes in cell signaling, allowing the research team to study signaling pathways in new ways.

“When you send cells into space, in particular cancer cells, the signaling inside the cells changes considerably,” Robinson said. “These changes occur quite fast, and we don’t really understand exactly what those changes are and what causes them.”

When cells mutate uncontrollably, they turn into cancer cells through a process known as tumorigenesis. By studying cell signaling within cancer cells and healthy cells, MicroQuin hopes to better understand how changes in signaling may lead to cancer development.

“We’re really trying to determine what the key pathways are behind cancer-like development, tumorigenesis, and oncogenesis,” Robinson said. “We think this study will help us understand that a bit better, and ultimately, we will better understand how the environment of the cancer cell changes.”

In their experiment, the research team will examine microgravity-induced changes in the breast and prostate cancer cells compared with each other and compared with healthy cells. The team will also observe how the cancer cells change in response to MicroQuin’s therapeutic, which targets an integral intracellular protein called TMBIM6. This particular protein helps regulate cellular stress, and research indicates that it also plays an essential role in cancer development. “There’s not a single cancer that does not rely on this protein in some way,” Robinson said.

By conducting this investigation in the stressful microgravity environment, the team hopes to better understand exactly what role TMBIM6 proteins play and how they can be used to develop cancer therapies. Results could help MicroQuin refine its cancer therapeutic and develop additional drugs for targeted treatment of breast, prostate, and other cancers.

Northrop Grumman CRS-17 is slated to launch from Wallops Flight Facility no earlier than February 19 at 12:39 p.m. EST. This mission will include more than 15 ISS National Lab-sponsored payloads. To learn more about all ISS National Lab-sponsored research on Northrop Grumman CRS-17, please visit our mission overview page.

Media Contact:
Patrick O’Neill
904-806-0035
PONeill@ISSNationalLab.org

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About the International Space Station (ISS) U.S. National Laboratory: The International Space Station (ISS) is a one-of-a-kind laboratory that enables research and technology development not possible on Earth. As a public service enterprise, the ISS National Lab allows researchers to leverage this multiuser facility to improve life on Earth, mature space-based business models, advance science literacy in the future workforce, and expand a sustainable and scalable market in low Earth orbit(Abbreviation: LEO) The orbit around the Earth that extends up to an altitude of 2,000 km (1,200 miles) from Earth’s surface. The International Space Station’s orbit is in LEO, at an altitude of approximately 250 miles.. Through this orbiting national laboratory, research resources on the ISS are available to support non-NASA science, technology and education initiatives from U.S. government agencies, academic institutions, and the private sector. The Center for the Advancement of Science in Space (CASIS(Abbreviation: CASIS™) The nonprofit organization that manages the ISS National Lab, which receives at least 50 percent of the U.S. research allocation on the International Space Station to facilitate research that benefits humanity (NASA manages the other 50% and focuses on research for space exploration purposes).) manages the ISS National Lab, under cooperative agreementA cooperative agreement is Federal assistance that establishes a relationship between the U.S. Government and a recipient in which the principal purpose of the relationship is to accomplish a public purpose of support or stimulation.  Since 2011, the Center for the Advancement of Science in Space™ (CASIS™) has managed the National Laboratory® through a Cooperative Agreement with NASA. with NASANational Aeronautics and Space Administration, facilitating access to its permanent microgravity research environment, a powerful vantage point in low Earth orbit, and the extreme and varied conditions of space. To learn more about the ISS National Lab, visit issnationallab.org.

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