ISS National Lab Research Announcement Seeking Tissue Engineering and Biomanufacturing Proposals Opens

KENNEDY SPACE CENTER (FL), October 3, 2022 – A research announcement to leverage the unique microgravityThe condition of perceived weightlessness created when an object is in free fall, for example when an object is in orbital motion. Microgravity alters many observable phenomena within the physical and life sciences, allowing scientists to study things in ways not possible on Earth. The International Space Station provides access to a persistent microgravity environment. environment of the International Space Station (ISSInternational Space Station) for in-space production applications within the biomedical community is now open. The ISS National Laboratory is specifically soliciting research concepts that seek to enhance tissue engineering and biomaterials that could be developed or manufactured in low Earth orbit(Abbreviation: LEO) The orbit around the Earth that extends up to an altitude of 2,000 km (1,200 miles) from Earth’s surface. The International Space Station’s orbit is in LEO, at an altitude of approximately 250 miles. (LEO). Through in-space production and manufacturing efforts, the ISS National Lab seeks to enable new business models that can grow capital investment and develop a robust market in LEO. Both NASANational Aeronautics and Space Administration and the ISS National Lab have prioritized utilization of the space station for in-space production applications(Abbreviation: InSPA) InSPA is an applied research and development program sponsored by NASA and the ISS National Lab aimed at demonstrating space-based manufacturing and production activities by using the unique space environment to develop, test, or mature products and processes that could have an economic impact. and manufacturing opportunities, and this research announcement reflects a desire to build on this growing area of emphasis.

The ISS National Lab is seeking proposals in the areas of regenerative medicine and biofabrication as well as associated technologies that may benefit from the unique environment of the space station. Of particular interest are studies that propose to:

• Exploit the benefits of stem cell research in the microgravity environment for therapeutic applications on Earth
• Demonstrate an organoid or multicellular culture system to model human diseases that can be used for testing therapeutics
• Develop or leverage existing systems on the space station for the production of tissues or other biocompatible materials for regenerative medicine

Under sponsorship of the ISS National Lab, Redwire Space will launch an enhanced BioFabrication Facility (BFF(Abbreviation: BFF) The BFF is a 3D bioprinter on the ISS capable of printing human tissue from bioinks mixed with living cells. This ISS National Lab commercial facility is owned and operated by Redwire Space.) on the next Commercial Resupply Services mission(Abbreviation: CRS mission) A CRS mission is a cargo resupply mission contracted by NASA to deliver supplies and research to the International Space Station on commercial spacecraft as part of the CRS contract with three commercial companies. As part of CRS missions, experiments currently return to Earth on SpaceX Dragon spacecraft that splash down in the ocean. (funded by NASA) to the space station. The company seeks to enable effective ways of printing human tissues and, potentially one day, organs for patients on Earth and for future space travelers. Researchers believe the space environment is beneficial for biofabrication because microgravity allows delicate tissues to mature and strengthen without collapsing under their own weight as they do on Earth. If validated, the BFF will be a forthcoming facility available for researchers to use to further in-space production applications.

Another ISS National Lab-sponsored project on that same mission is from a team of researchers at Emory University who will look to microgravity as an environment that speeds up the growth of human cardiac muscle cells. Results from this investigation, which is funded by the U.S. National Science Foundation, could lead to the development of therapies to replace damaged cells in patients with heart disease on Earth.

Both of these projects are examples of how researchers can take advantage of the novel environment onboard the space station to advance in-space production applications. Findings from such investigations will help improve patient care on Earth and aid in the development of technologies applicable to future space platforms and/or strengthening commerce in LEO.

This research announcement follows a two-step proposal process. The Step 1: Concept Summary is due at the close of business on November 29, 2022. Only approved Step 1 concepts will be invited to submit a full proposal. For more information on this research announcement, including how to attend an upcoming webinar slated for October 13, 2022, please visit our research announcement overview webpage. To learn more about the ISS National Lab and the science that it sponsors, please visit our website.

Image: ESA astronaut Thomas Pesquet conducts biomedical research on the ISS.

Media Contact:       
Patrick O’Neill
904-806-0035
PONeill@ISSNationalLab.org

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About the International Space Station (ISS) U.S. National Laboratory: The International Space Station (ISS) is a one-of-a-kind laboratory that enables research and technology development not possible on Earth. As a public service enterprise, the ISS National Lab allows researchers to leverage this multiuser facility to improve life on Earth, mature space-based business models, advance science literacy in the future workforce, and expand a sustainable and scalable market in low Earth orbit. Through this orbiting national laboratory, research resources on the ISS are available to support non-NASA science, technology and education initiatives from U.S. government agencies, academic institutions, and the private sector. The Center for the Advancement of Science in Space (CASIS(Abbreviation: CASIS™) The nonprofit organization that manages the ISS National Lab, which receives at least 50 percent of the U.S. research allocation on the International Space Station to facilitate research that benefits humanity (NASA manages the other 50% and focuses on research for space exploration purposes).) manages the ISS National Lab, under cooperative agreementA cooperative agreement is Federal assistance that establishes a relationship between the U.S. Government and a recipient in which the principal purpose of the relationship is to accomplish a public purpose of support or stimulation.  Since 2011, the Center for the Advancement of Science in Space™ (CASIS™) has managed the National Laboratory® through a Cooperative Agreement with NASA. with NASA, facilitating access to its permanent microgravity research environment, a powerful vantage point in low Earth orbit, and the extreme and varied conditions of space. To learn more about the ISS National Lab, visit issnationallab.org.

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