Engineered Cardiac Tissues to Fly on NG-18 to Advance Treatments for Heart Disease
WALLOPS ISLAND (VA), October 26, 2022 – Heart disease may be the leading cause of death in the United States, but researchers from Emory University are working toward a solution. The research team will leverage the International Space Station (ISSInternational Space Station) National Laboratory to examine how microgravityThe condition of perceived weightlessness created when an object is in free fall, for example when an object is in orbital motion. Microgravity alters many observable phenomena within the physical and life sciences, allowing scientists to study things in ways not possible on Earth. The International Space Station provides access to a persistent microgravity environment. affects the growth and function of cardiomyocytes (heart muscle cells) into tissue-like structures. Findings will help advance cardiac disease modeling and could lead to the development of new therapies to treat heart disease in patients on Earth.
The project, funded by the U.S. National Science Foundation and supported by ISS National Laboratory, will launch on Northrop Grumman’s 18th Commercial Resupply Services mission(Abbreviation: CRS mission) A CRS mission is a cargo resupply mission contracted by NASA to deliver supplies and research to the International Space Station on commercial spacecraft as part of the CRS contract with three commercial companies. As part of CRS missions, experiments currently return to Earth on SpaceX Dragon spacecraft that splash down in the ocean..
Scientists hypothesize that in the absence of gravity, cardiac cells will grow differently, which could lead to advancements essential for use in regenerative medicine, disease modeling, and the development of more effective drugs. To that end, Chunhui Xu, a professor in the department of pediatrics at Emory University, proposes studying how cardiac myocytes derived from human induced pluripotent stem cells (hiPSCs) grow in microgravity.
“These types of cells can be used to replace damaged cells in patients with heart disease,” Xu said. “However, stem cell-derived cardiac cells are immature compared to the same cells in our bodies; they’re more like fetal or embryonic cardiac cells.”
Xu says that more mature cells are needed to transplant into patients with heart disease because by transplanting immature cells into patients, there is an increased risk of complications like arrhythmia. To that end, Xu’s investigation will focus on the maturation of stem cell-derived cardiac muscle cells into microtissues. She says the key to producing more mature cells is understanding how they grow and function—and the best place to do that is on the ISS. That is because exposure and growth of the cells into microtissues in microgravity is expected to reduce tension between cells and improve the tissue architecture.
“Microgravity is really amazing; the cells can sense what kind of environment they’re in and adapt to it,” Xu said. “As such, the ISS provides a unique environment that’s perfect for helping us discover new things that aren’t possible anywhere else.”
According to Xu, the cells launching on NG-18 will be cryopreserved until they reach the ISS, where they will be thawed and allowed to mature for an estimated seven days. Then the resulting tissues will be preserved and returned to Earth for analysis.
NG-18 is targeted for launch from Wallops Island no earlier than November 6 at 5:50 a.m. EDT. This mission will include more than 20 ISS National Lab-sponsored payloads. To learn more about all ISS National Lab-sponsored research on NG-18, please visit our launch page.
Download a high-resolution photo for this release: NG-18 Research from Emory University
Media Contact:
Patrick O’Neill
904-806-0035
PONeill@ISSNationalLab.org
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About the International Space Station (ISS) National Laboratory: The International Space Station (ISS) is a one-of-a-kind laboratory that enables research and technology development not possible on Earth. As a public service enterprise, the ISS National Lab allows researchers to leverage this multiuser facility to improve life on Earth, mature space-based business models, advance science literacy in the future workforce, and expand a sustainable and scalable market in low Earth orbit(Abbreviation: LEO) The orbit around the Earth that extends up to an altitude of 2,000 km (1,200 miles) from Earth’s surface. The International Space Station’s orbit is in LEO, at an altitude of approximately 250 miles.. Through this orbiting national laboratory, research resources on the ISS are available to support non-NASA science, technology and education initiatives from U.S. government agencies, academic institutions, and the private sector. The Center for the Advancement of Science in Space (CASIS(Abbreviation: CASIS™) The nonprofit organization that manages the ISS National Lab, which receives at least 50 percent of the U.S. research allocation on the International Space Station to facilitate research that benefits humanity (NASA manages the other 50% and focuses on research for space exploration purposes).) manages the ISS National Lab, under Cooperative AgreementA cooperative agreement is Federal assistance that establishes a relationship between the U.S. Government and a recipient in which the principal purpose of the relationship is to accomplish a public purpose of support or stimulation. Since 2011, the Center for the Advancement of Science in Space™ (CASIS™) has managed the National Laboratory® through a Cooperative Agreement with NASA. with NASANational Aeronautics and Space Administration, facilitating access to its permanent microgravity research environment, a powerful vantage point in low Earth orbit, and the extreme and varied conditions of space. To learn more about the ISS National Lab, visit issnationallab.org.
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